MPs isolated from patients during active LN showed an increased reactivity with the anti-histone antibodies KM-2 and LG11-2, targeting apoptosis-induced acetylated histone H4 (at K8,12,16) and H2B (at K12), respectively, when compared to MPs from the same patients during remissive LN or patients without LN (Figures 1A–C). Here, H2BC21 is linked to lobular neoplasia.