The same holds true for cancer recognition, and for instance an HLA-A02-binding epitope derived from the TMH of melanoma antigen recognized by T-cells 1 (Mart1; also known as Melan-A; residues 26–35) (30) is strikingly immunodominant, with few other MHC-I epitopes described (31). The gene discussed is MLANA; the disease is melanoma.