For instance, DSCAM-AS1, one of the Apo-ERα-Regulated lncRNAs (AER-lncRNAs) is expressed in breast cancer with ER-alpha positive (ERα +) status and correlates inversely with epithelial-to-mesenchymal transition (EMT), and was confirmed as a tumor suppressor in luminal-like breast cancer31. The gene discussed is ESR1; the disease is breast cancer.