Many differentially expressed lncRNAs including circulating lncRNA and lncRNA signatures, such as H1915, lncRNA HOX antisense intergenic RNA (HOTAIR)16, 12-lncRNA signature17 and breast cancer anti-estrogen resistance 4 (BCAR4)18 have been detected in breast cancer plasma, tissues and cell lines. The gene discussed is BCAR4; the disease is breast cancer.