Moreover, messenger RNA (mRNA) expression of cardiac hypertrophy markers Nppa and Myh7 was significantly lower in LV free walls (LVFWs) in Tcf21MCM;Ctnnb1fl/fl and PostnMCM;Ctnnb1fl/fl mice compared to controls after TAC (Fig. 3i−l). Here, NPPA is linked to cardiac hypertrophy.