AKT1 and cancer: Chemokines have been shown to associate with cancer metastasis as well as tumor angiogenesis, and work by activating some signaling pathways, including extracellular regulated protein kinases (ERK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), and phosphoinosmde-3-kinase (PI3K)/the mammalian target of rapamycin (mTOR).