CCR4 and hepatocellular carcinoma: Furthermore, we used HCC tissue microarray section to examine the correlation between CCR4 expression and clinicopathologic features, and found there was high expression of CCR4 which is associated with more vascular invasion (P = 0.001), and TNM stage (P = 0.013), but not with other clinicopathological factors including sex, age, cirrhosis and tumor diameter etc. (Table 1).