CD44 and cancer: Nanoparticles based on hyaluronic acid (HA) have received a wide attention for targeted cancer therapy as HA, a biocompatible and biodegradable natural polysaccharide (Toole, 2004; Liang et al., 2016), has an intrinsic binding affinity to CD44 that is overexpressed in many tumor cells (Cadete & Alonso, 2016; Dosio et al., 2016; Rao et al., 2016).