Although in systematic review eight polymorphisms, including MMP2 C-735T, MMP7 A-181G, MMP8 rs11225395, MMP9 rs6094237, MMP12 rs2276109, MMP20 rs2292730, MMP20 rs12278250, MMP20 rs9787933, might be associated with ovarian cancer risk, it was inconclusive results due to lack of relevant studies. The gene discussed is MMP12; the disease is ovarian carcinoma.