Gao lab and Chandran lab demonstrated that vital host pathways ERK (Extracellular signal-Regulated Kinase)/MAPK (Mitogen-Activated Protein Kinase) and FAK (Focal Adhesion Kinase)/PI3K (Phosphoinositide 3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase) /PKC (Protein kinase C) are essentially required for KSHV primary infection [40–42]. The gene discussed is PTK2; the disease is infection.