As a post hoc analysis, to investigate to what extent locus 1 (in PHACTR1) was driving the enrichment of cross-phenotype associations between migraine and CAD, we re-performed the enrichment analysis after excluding all SNPs in PHACTR1 as well as any SNPs in LD (r2 > 0.1) with these. The gene discussed is PHACTR1; the disease is migraine disorder.