The index SNPs at two of the three loci (locus 1 in PHACTR1 and locus 3 in AS3MT) show opposite effect directions in migraine and CAD, which corresponds with recent reports that CAD risk alleles overall are under-represented in migraine patients [15], and that migraine risk alleles are under-represented in CAD [16]. This evidence concerns the gene PHACTR1 and coronary artery disorder.