Locus 1 is intragenic in PHACTR1 (encoding phosphatase and actin regulator 1 protein), and is the strongest shared risk locus between migraine and CAD in the analyses based on either C4D or CARDIoGRAM (conjunctional FDR for index SNP = 3.50 x 10−5 and 3.90 x 10−5, respectively). Here, PHACTR1 is linked to coronary artery disorder.