PNPLA3 and metabolic dysfunction-associated steatotic liver disease: PolyPhen-2 predicted that three missense variants are “probably damaging” to the protein function of genes TRIM58, PLD1 and PNPLA3. Variant rs2075995 was predicted to be “possibly damaging” to the protein function of gene E2F2. TRIM58 is a ubiquitin ligase induced during late erythropoiesis [11]; PLD1 is a phospholipase implicated in processes including membrane trafficking [11]; PNPLA3 is a triacylglycerol lipase in adipocytes and variant rs738409 is associated with susceptibility to Non-alcoholic Fatty Liver Disease [12].