The lower expression of SYK(T) and SYK(S) in tumors harboring a PTEN mutation supports the findings of a previous study on diffuse large B-cell lymphomas in which a subset of samples exhibited an increase in the SYK gene copy number variation while a different subset exhibited loss of PTEN suggesting two independent mechanisms to promote cell survival [33]. This evidence concerns the gene SYK and diffuse large B-cell lymphoma.