SYK and Hand-foot syndrome: In this analysis, both continuous mRNA expression levels of SYK(S) and nodal status remained significantly associated with HFS (HR = 1.83; 95% CI = 1.08–3.12; p = 0.026 and HR = 1.27; 95%CI = 1.01–1.60; p = 0.042) (Table 2).