To our knowledge, one previous study of colorectal cancer patients explored the prognostic role of SYK. Yang et al. showed that methylation of the SYK gene promoter region was associated with decreased SYK mRNA and SYK protein expression, and subsequently showed a significantly worse five-year OS in the group with methylated SYK gene promoter region compared to the group with unmethylated SYK gene promoter region (5-year overall survival 59% vs 80% p<0.001, respectively [13]. Here, SYK is linked to colorectal cancer.