IL-6 is best described as a pro-tumorigenic cytokine, and together with other members of this family, it affects cell proliferation, survival, differentiation and migration [42], which includes an important role in the pathogenesis of IBD in human and murine by Th1; therefore, reduced IL-6 production is considered to be useful in treating colitis [43,44]. Here, IL6 is linked to inflammatory bowel disease.