We found that DHODH (P = 3.61×10−5), ITCH (P = 1.23×10−4), and TRPC4AP (P = 7.7x10-4) were among the top genes associated with ER-negative breast cancer risk, and TRPC4AP (P = 1.68×10−5) and DHODH (P = 1.12×10−4) among the top genes associated with the overall breast cancer risk using breast tissue eQTLs. The gene discussed is ITCH; the disease is breast carcinoma.