M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated (CD206) pathway [70], and tumor associated macrophages (TAMs) generally acquire an M2-like phenotype that plays important roles in many aspects of tumor growth and progression [71–74], and M2-polarized TAMs have also been found to promote the EMT in various carcinomas [75, 76]. Here, MRC1 is linked to neoplasm.