For HCC-specific survival, the univariate analysis showed that female gender (HR: 1.2, 95% CI: 1.02–1.38, p = 0.028), Child-Pugh A (HR: 4.1, 95% CI: 3.55–4.72, p <0.001), AFP <400 ng/ml (HR: 3.4, 95% CI: 2.86–3.99, p <0.001), BCLC stage 0/A (HR: 5.2, 95% CI: 4.37–6.15, p <0.001), curative therapy (HR: 4.9, 95% CI: 4.04–5.94, p <0.001), and the presence of EHPC (HR: 2.0, 95% CI: 1.39–2.86, p <0.001), with EHPC before HCC diagnosis (HR: 1.7, 95% CI: 1.16–2.54, p = 0.007) or with EHPC after HCC diagnosis (HR: 3.4, 95% CI: 1.42–8.24, p = 0.006), were all associated factors. This evidence concerns the gene AFP and hepatocellular carcinoma.