ESR1 and neoplasm: S8G and S8H Fig depicts associations between the presence of this amplification and patient clinico-pathological attributes. For example, in ER+/HER2+ patients (S8H Fig), the presence of 16p13 amplification is correlated with the luminal score of the tumor. In the lumA subtype, patients with the highest expression of the lightyellow SR module are significantly different than healthy controls (S8I Fig), and in the ER+/HER2+ subtype, patients with the lowest expression of the salmon module are significantly different than healthy controls (S8J Fig).