PRF1 and breast cancer: Finally, specifically for patients with large tumors, both the darkgrey module, which is enriched for MYC target genes, and the greenyellow module, which is enriched for genes involved in the lymphoid cell-mediated immunity (including GZMH, GZMB, GZMM, KLRD1, PRF1, KLRG1, and GNLY; S4 and S5 Tables), are underexpressed compared to the remaining BC patients and controls.