INS and type 2 diabetes mellitus: We further assessed the transcriptomic profiling in adipose (relevant to T2D and CVD) and aorta tissue (main site of CVD) in relation to 7 cardiometabolic phenotypes including adiposity, lipid levels (triglyceride, LDL, HDL), fasting glucose, fasting insulin and HOMA-IR, across >100 mouse strains in two HMDP panels [21–23].