CAV1 and type 2 diabetes mellitus: Thirdly, although we conducted validation experiments on the CAV1 subnetwork in both in vitro and in vivo models and cross-validated the importance of the predicted top key drivers and subnetworks in two independent large-scale mouse population studies, further experiments are warranted to thoroughly test the causality of the predicted KDs and elucidate the detailed tissue-specific mechanisms of the KDs on CVD and T2D.