HMGCR and type 2 diabetes mellitus: COL6A2, on the other hand, provides new insights into how collagen may affect cardiometabolic disorders: in adrenal tissue COL6A2 is connected to IGF1R, the direct downstream effector for KD IGF1. Importantly, our directionality analysis suggests that while some KDs such as CAV1 may have similar directional effects on CVD and T2D, cases like HMGCR that show opposite effects on these diseases are also present.