Candidate SNPs are: 1) in strong LD (r2 ≥ 0.08) with the most associated breast cancer GWAS SNP; 2) within DNase/ATAC-seq defined regulatory region of MCF7, MCF10A, T47D, HMEC or vHMEC cell lines and tissue; 3) contain high information content (IC) in the TF binding PSWM (IC ≥ 0.5); and 4) are eQTLs in breast cancer patient solid tumor sample and GTEx breast tissue. The gene discussed is TF; the disease is breast cancer.