Furthermore, one of the transcriptomic consensus molecular subtypes (CMS) of CRC described by Guinney and colleagues [12], the “metabolic subtype 3” (CMS3), exhibits a clear enrichment for multiple metabolism signatures along with KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog)-activating mutations that have been described as inducing metabolic reprogramming [12]. The gene discussed is KRAS; the disease is colorectal carcinoma.