ColoLipidGene signature encompasses the transcriptional activation of four metabolic-related genes: ACSL1, ABCA1 (ATP-Binding Cassette Subfamily-A Member 1), AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1), and SCD. Results from three different groups of patients, together with data from publicly available repository GEO (Gene Expression Omnibus Database), point out the activation of ABCA1, ACSL1, AGPAT1, and SCD as one of the main relevant metabolic factors in CRC malignant progression [10]. This evidence concerns the gene SCD and colorectal carcinoma.