INS and metabolic dysfunction-associated steatotic liver disease: This perfectly agrees with scientific evidence: in fact, various studies showed how simple sugars, and especially fructose, could be the basis of metabolic alterations supporting NAFLD: a recent review published in 2015, collecting studies involving both animals and humans, shows how fructose intake could worsen insulin sensitivity, increase de novo lipogenesis and the intrahepatic triglyceride storage, and how a low carb diet could partially reverse those findings [16].