Pratheeshkumar reported that, the arsenic induced lung cancer was induced by ROS-dependent activation of STAT3,3 while another study showed that arsenic bound to series of antioxidant proteins, such as peroxiredoxin, peroxide reductase, glutathione reductase, and glyceraldehyde-3-phosphate dehydrogenase.30 This evidence concerns the gene GSR and lung carcinoma.