As per individual proteins, the proliferation, migration, and tube formation of endothelial cells bearing CXCR1/2 chemokine receptors were increased in response to CXCL8/IL-8 and CXCL1/GRO-1 produced by ovarian cancer cells in a mechanism involving MMP-1-protease-activated receptor-1 (PAR1) activation. This evidence concerns the gene F2R and ovarian cancer.