OPA1 and Parkinson disease: In 1 previous report, a form of syndromic PD with dementia, neuropathy, and deafness was associated with OPA1 mutations.6 Dysregulated mitophagy and mitochondrial networks have also been detected in OPA1 patient cells.7 This report further implicates OPA1 in nonsyndromic, idiopathic PD associated with abnormal cristae morphology and mitochondrial networks.