Results from these studies show that mice deficient for inflammasome components, including NLRP3, caspase-1, NLRP1, NLRP6, and NLRC4, are highly susceptible to colitis-associated colon cancer induced by AOM/DSS by displaying severe intestinal inflammation, and increased number of colon polyps (22–29). The gene discussed is NLRC4; the disease is infectious otitis media.