NLRP3 and CINCA syndrome: Mutations in the human NLRP3 gene is associated with a group of autoimmune diseases termed as cold-induced auto-inflammatory syndrome, including familial cold-induced auto-inflammatory syndrome, Muckle–Wells syndrome, and NOMID/CINCA (neonatal onset multisystem inflammatory disorder or chronic infantile neurologic cutaneous and articular syndrome) (34, 64–67).