C3 and autoimmune uveitis: These results, together with previous reports by ourselves and others showing that complement components accumulated adjacent to sites of inflammation in EAU (35), that C3 KO mice (21) and C3aR/C5aR KO mice (23) develop less severe EAU than WT mice, and that treating WT mice with complement inhibitors, such as recombinant DAF (22), soluble Crry (21), or an anti-C5 mAb (36), reduces the severity of EAU, confirm a critical role of the complement system in the pathogenesis of EAU and raise the possibility that it may influence its human counterpart, autoimmune uveitis.