LIF and multiple sclerosis: Factor B KO mice are resistant to induction of experimental autoimmune encephalomyelitis (EAE), a primarily T cell-mediated model of multiple sclerosis, and show reduced T cell responses (37), inhibition of the alternative pathway using an anti-factor B mAb suppresses T cell responses in experimental autoimmune anterior uveitis in rats (38), and, more directly, splenocytes from factor D KO mice stimulate significantly reduced T cell responses in a mixed lymphocyte reaction assay (10).