Indeed, targeting the angiopoietin 2 (ANG2)/Tie2 pathway, with an anti-ANG2 antibody, inhibits tumor growth and metastasis by disabling the pro-angiogenic activity of Tie2-expressing monocytes/macrophages and impeding the emergence of evasive resistance to antiangiogenic therapy (88). The gene discussed is ANGPT2; the disease is neoplasm.