Certain autoantibodies, such as anti-ribosomal P, anti-neurofilament, anti-endothelial, anti-Ro, or anti-Smith antibodies have been associated with neuropsychiatric manifestations other than cognitive impairment, whereas anti-neuronal, antiphospholipid, and anti-double stranded DNA (dsDNA) antibodies cross-reactive with the N-methyl-d-aspartate receptor (NMDAR) subunits GluN2A or GluN2B (anti-NR2) have been linked to neurocognitive impairment in SLE (44–48). Here, GRIN2B is linked to systemic lupus erythematosus.