CD40LG and autoimmune thrombocytopenic purpura: While AID-deficient humans with hyper-IgM have an increased risk of autoimmune and inflammatory disorders such as diabetes mellitus, polyarthritis, autoimmune hepatitis, hemolytic anemia, immune thrombocytopenia, Crohn’s disease, and chronic uveitis, there is no clear documentation of SLE in these patients (71).