While AID-deficient humans with hyper-IgM have an increased risk of autoimmune and inflammatory disorders such as diabetes mellitus, polyarthritis, autoimmune hepatitis, hemolytic anemia, immune thrombocytopenia, Crohn’s disease, and chronic uveitis, there is no clear documentation of SLE in these patients (71). The gene discussed is AICDA; the disease is systemic lupus erythematosus.