KCNH2 and torsades de pointes: Animal studies accuracy is higher when predicting QT prolongation rather that in vivo TdP risk: 85 and 79% for 19 compounds based on QT prolongation in in vivo dog studies and hERG assays, respectively (Valentin et al., 2009; Wallis, 2010); 90% accuracy for 40 compounds based on non-rodent QT prolongation (Vargas et al., 2015).