Elevated Glut1 expression (Chung et al., 2009; Saigusa et al., 2012) and high insulin levels (Wolpin et al., 2009) have been associated with CRC stage of poor prognosis and Glut 1 has been considered as a potential therapeutic target to control the glucose uptake by the cells to limit the proliferative capacity of the CRC cells. The gene discussed is INS; the disease is colorectal carcinoma.