In addition, many clinical studies have emphasized the association of MMP expression with progression of cervical cancer (Zhou et al., 2002; Asha Nair et al., 2003), and many types of human tumor have been reported to be associated with increased expression of MMP-2 (Di Nezza et al., 2002; Sato et al., 2004; Berube et al., 2005). This evidence concerns the gene MMP2 and cervical carcinoma.