Studies have shown that visceral fat produced more angiotensin, interleukin-6 and plasminogen activator inhibitor than subcutaneous fat did, (Wajchenberg et al., 2001) it had closer correlation with hypertension, diabetes, metabolic syndrome, (Liu et al., 2010) and was more important than BMI as a cardiovascular risk. The gene discussed is SERPINB2; the disease is diabetes mellitus.