FBXW7 and familial pancreatic carcinoma: Treatment of cultured pancreatic cancer cells with genistein downregulated the expression of miR-223 and miR-34a which increased the levels of their target proteins F-box and WD repeat domain-containing 7 (Fbw7) and Notch-1 and reduced growth (Xia et al., 2012; Ma et al., 2013).