PSMB5 and fragile X-associated tremor/ataxia syndrome: The PM is associated with disorders distinct from FXS, including fragile-X-associated tremor/ataxia syndrome (FXTAS), an adult-onset neurological disorder (Hagerman et al., 2001) affecting primarily males, as well as fragile-X-associated primary ovarian insufficiency (FXPOI), and the fragile-X-associated diminished ovarian reserve (FXDOR) in female carriers: all of which we will expand upon in this review.