Ovarian function is to deteriorate over a period of months to years and progress from an occult stage, which may manifest only by reduced fecundity, through a phase of biochemical manifestation (also elevated FSH levels), reaching the final stage of overt ovarian insufficiency characterized by irregular or absent menses, along with reduced fecundity and elevated FSH levels (Welt, 2008). This evidence concerns the gene BRD2 and ovarian dysfunction.