HIF1A and neoplasm: The abundance of NDRG3 correlated with the production of lactate, which resulted from the HIf1α–transcriptionally induced changes in metabolism, enhancing tumor cell growth and angiogenesis.(23) We found that NDRG3 levels were elevated in the colitic mucosa of fasted-refed mice compared with mucosa in non-fasted mice (Fig. 3D).