SREBF1 and fatty liver disease: Peroxisome proliferator-activated receptor (PPAR) α, highly expressed in liver, is closely related with fatty acid β-oxidation and knockout of hepatocyte PPARα gene could cause hepatic steatosis.(17) In this study, we investigated the effects of long-term consumption of soy isoflavone on hepatic steatosis induced by high fat diet (HFD), and chose SREBP-1c and and PPARα pathways as the targets to investigate the possible mechanisms.