SREBP-1c can bind to the promoters regions of its target genes, and then promote the transcript of lipogenic enzyme; interestingly SREBP-1c can also combine with its own promoter and activate the expression of itself; in addition, it can be activated by liver X receptor (LXR).(27) In NAFLD, hepatic expression of SREBP1-c and FAS were elevated, this may be a causative reason for the increasing of lipid production in liver. Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.