In order to characterize the effects of SMPD1 in the setting of acute- and post-acute liver dysfunction following the host response during sepsis, we opted for different inhibition strata: As a model of pharmacological inhibition, we preventively treated smpd1+/+ animals (p-smpd1+/+) for seven days prior to the induction of sepsis with desipramine, a well-known functional inhibitor of SMPD1 (FIASMA)26. The gene discussed is SMPD1; the disease is Sepsis.