Taken together with data from other studies which show that the suppression of POPDC1 promotes cell migration and invasion in glioblastoma, hepatocellular carcinoma, gastric cancer and colorectal cancer [12,13,25,27], these data provide strong evidence to support the hypothesis that the dysregulation of POPDC1 promotes malignant phenotypes in breast cancer. This evidence concerns the gene POPDC1 and colorectal cancer.