Restoring rac2 expression in the miR-722-overexpressing line increased susceptibility, to levels comparable to the wild-type larvae, from the acute systemic Pseudomonas infection (Fig. 4G), suggesting that miR-722 protects zebrafish from lethal inflammatory challenge via the suppression of rac2. In wild-type larvae, the endogenous level of miR-722 was not upregulated during systemic inflammation (Fig. 4H). This evidence concerns the gene RAC2 and Pseudomonas infection.