Recently, a long-term 10-year follow-up of Chemo N0 participants confirmed the prognostic value of uPA/PAI-1 in N0 breast cancer, especially in grade II tumours (hazard ratio, 1.94; 95% confidence interval: 1.16–3.24; P = 0.01) [12]. Here, SERPINE1 is linked to breast carcinoma.