A similar concept of isolating ICC progenitors, for example, using the KitlowCD44+CD34+Insr+Igf1r+ phenotype used to obtain mouse ICC precursor cells [30] from organoids, and seeding them into damaged tissue, might allow for self-migration, alignment, and differentiation into specific ICC types in vivo, and accompanying restoration of gut motility. Here, IGF1R is linked to intrahepatic cholangiocarcinoma.