Data on the interaction of FTO polymorphisms with dietary patterns are rare in Asians and Middle-Eastern populations [5], which is why the aim of the current study was to investigate whether the Med Diet could interact with FTO gene polymorphisms (rs1121980, rs1421085, rs9939973, rs8050136, rs17817449, and rs3751812) in isolation or in a combined-form genetic risk score (GRS) in relation to obesity phenotypes among participants of the Tehran Lipid and Glucose Study (TLGS). Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.