NFE2L2 and Alzheimer disease: Nrf2 is one of the most important cellular defense mechanisms against oxidative stress and is involved in the protection against some neurodegenerative diseases (AD, PD, HD, MS, and cerebral ischemia) by activating a battery of cytoprotective genes through interaction with the ARE [71,72,73,74,75,85,86,87,97,98,99].