BRAF and metastatic melanoma: Another prospective, randomized, open label, multi-center, parallel group, three-arm phase III study is in progress to study the efficacy and safety of binimetinib with LGX818 (encorafenib) compared vemurafenib and LGX818 monotherapy in locally advanced unresectable or metastatic melanoma with BRAF V600 mutation (ClinicalTrials.gov number, NCT01909453).