The open-label and non-randomized phase II study assessed the safety and efficacy of single-agent binimetinib in adult patients with locally advanced and unresectable or metastatic malignant cutaneous melanoma, harboring BRAF V600E or NRAS (a member of the RAS gene family) mutations (ClinicalTrials.gov number, NCT01320085). Here, NRAS is linked to cutaneous melanoma.