KRAS and non-small cell lung carcinoma: A randomized Phase II study for KRAS-mutated NSCLC did show very promising results for selumetinib + docetaxel vs. docetaxel, with significant improvement in median PFS (5.3 vs. 2.1 months, p = 0.014) and objective response rate (37% vs. 0%, p < 0.0001) when compared with the docetaxel monotherapy cohort, and the overall survival benefit is 9.4 vs. 5.2 months (p = 0.21), with higher toxicity and the overall survival benefit (9.4 vs. 5.2 months, p = 0.21), with high toxicity.