IGF-1 activation can be beneficial or harmful depending on the stage of the disease when using the hippocampal culture model of post-traumatic epileptogenesis [30] However, in an animal model, treatment with IGF-I decreased seizure severity, increased hippocampal neurogenesis, and protected against neurodegeneration and was considered to be a possible potential treatment in temporal lobe epilepsy [31]. The gene discussed is IGF1; the disease is temporal lobe epilepsy.