To assess whether the glucose intolerance of Fh1βKO mice is mediated by HIF1α stabilization, we crossed Fh1βKO and Hif1αfl/fl mice (Cramer et al., 2003) to produce β cell-specific deletion of both Fh1 and Hif1α (Fh1Hif1αβKO mice). This evidence concerns the gene HIF1A and Glucose intolerance.