AKT1 and infection: These findings are corroborated by infection of Akt1/2+/+ and Akt1/2-/- cells with WSN or WSNΔNS1, which show that AKT is required for WSNΔNS1 induction of mTORC1 activity (Fig 2C) and that, as in Vero cells, WSNΔNS1 infected Akt1/2+/+ cells promoted mTORC1 activity with low levels of p-AKT(T308) and in the absence or barely detectable levels of p-AKT(S473) (Fig 2D).