PDPK1 and infection: To ascertain the kinase responsible for phosphorylation on residue T308 of AKT during infection and its potential relationship with mTORC1 activation, we first infected wild-type and Tbk1-/- cells with WSN in the absence or presence of BX795, an inhibitor of PDPK1 [34], TBK1 and IKKε [35].