We assessed AKT and mTORC1 activation simultaneously with REDD1 protein levels during viral infection and found that mTORC1 activity was strongest (as compared to the mock counterpart for each time point normalized to total S6K levels) when REDD1 levels were greatly diminished and AKT T308 phosphorylation was strongest by 7h post-infection (Fig 4A and S5 Fig). Here, DDIT4 is linked to viral infectious disease.