Similar results were obtained when mice treated between days -1 and 3 p.i. with αIL-6 were infected with mouse adapted H1N1 IAV PR8 (strain A/Puerto Rico/8/1934 H1N1), with IL-6 depleted mice showing delayed recovery from infection and reduced IL-6, IL-10 and IL-27 in the airways at day 10 p.i. (S4A and S4B Fig). This evidence concerns the gene IL27 and infection.