CR2 and malaria: To gain insight into the regulators of atypical MBC differentiation we analyzed publicly available genome-wide expression data we generated from naïve B cells (CD19+CD21+CD27−), classical MBCs (CD19+CD21+CD27+) and atypical MBCs (CD19+CD21−CD27−) isolated from the peripheral blood of adults with lifelong malaria exposure (S1 Table) [5].