This could be due to suboptimal adherence of the laboratory to pre-analytic recommendations to obtain reliable results[34] or on specific alterations of the individual components of the patented panels that could occur following LT due to chronic inflammation (elevation of alpha-2-macroglobulin, hyaluronan), hemolytic anemia (haptoglobin), multidrug induction (GGT) or cholestasis (bilirubin). This evidence concerns the gene A2M and cholestasis.